https://chromosomesandcancer.com/2021/10/24/walk-for-mds/2021-10-24T09:53:44+00:00monthlyhttps://chromosomesandcancer.com/2020/10/25/mds-aware-susan-sontag/2020-10-25T10:02:58+00:00monthlyhttps://chromosomesandcancer.com/2019/07/14/a-myeloid-gene-panel-for-better-mds-patient-care/2019-07-14T01:16:12+00:00monthlyhttps://chromosomesandcancer.com/2017/07/19/discovering-cancers-causes-with-the-help-of-mds/https://chromosomesandcancer.com/wp-content/uploads/2017/07/dic-20-22.jpgdic 20-22The arrow points to green dots in the middle of a chromosome. This is the left-over telomere signature that tells us that this abnormal chromosome was made by the joining together of sticky chromosome ends that had their telomeres eroded away. The other green dots are at the chromosome ends. The left and right photos show the same cell but in the right one the abnormal chromosome is identified by its red and blue label.2017-09-04T13:55:18+00:00monthlyhttps://chromosomesandcancer.com/2016/07/31/dna-origami/2016-08-02T02:28:00+00:00monthlyhttps://chromosomesandcancer.com/2015/03/17/why-chromosomes/2016-07-30T12:30:17+00:00monthlyhttps://chromosomesandcancer.com/2016/07/14/chromosome-analysis-and-mds/https://chromosomesandcancer.com/wp-content/uploads/2016/07/del20q1.jpgdel20qNormal 20 (left) and abnormal 20 missing most of the long arm ("del(20q)").https://chromosomesandcancer.com/wp-content/uploads/2016/07/del20q.jpgdel20qNormal 20 (left) and abnormal 20 missing most of the long arm ("del(20q)").https://chromosomesandcancer.com/wp-content/uploads/2016/07/del20q-male.jpgdel20q male2018-04-15T01:06:13+00:00monthlyhttps://chromosomesandcancer.com/2015/07/14/mr-dahl-and-his-not-so-fantastic-mds/https://chromosomesandcancer.com/wp-content/uploads/2015/07/book-2.jpgbook 22015-07-16T04:34:17+00:00monthlyhttps://chromosomesandcancer.com/2015/04/30/chromosome-folding-theory-shows-promise-eurekalert-science-news/2015-04-30T04:19:49+00:00monthlyhttps://chromosomesandcancer.com/2015/03/22/theleukaemiaproject-com/2015-03-22T06:13:40+00:00monthlyhttps://chromosomesandcancer.com/2015/03/04/stop-leukaemia/https://chromosomesandcancer.com/wp-content/uploads/2015/03/nicholas-drawing-e1425459748772.jpgNicholas drawingStop Leukemia - by Nicholas2015-03-04T09:05:13+00:00monthlyhttps://chromosomesandcancer.com/the-leukaemia-project/2015-02-24T05:46:07+00:00weekly0.6https://chromosomesandcancer.com/2015/02/23/resbaz-research-tools/2015-02-23T23:07:48+00:00monthlyhttps://chromosomesandcancer.com/2015/02/01/discovering-dna/https://chromosomesandcancer.com/wp-content/uploads/2015/02/dna-tools.jpgDNA toolS2015-02-01T20:57:02+00:00monthlyhttps://chromosomesandcancer.com/2014/12/30/2014-in-review/2014-12-30T10:09:22+00:00monthlyhttps://chromosomesandcancer.com/2014/12/29/the-world-needs-to-know-about-the-bangladesh-oil-spill-it-affects-us-all/https://chromosomesandcancer.com/wp-content/uploads/2014/12/79f8b-1a4b8092.jpg79f8b-1a4b80922014-12-29T10:45:51+00:00monthlyhttps://chromosomesandcancer.com/2014/12/19/genome-sequencing-exploring-the-diagnostic-promise/https://chromosomesandcancer.com/wp-content/uploads/2014/12/hanners.jpgHanners Family2014-12-18T19:14:00+00:00monthlyhttps://chromosomesandcancer.com/2014/12/10/chromosomes-that-cause-cancer-part-4-chromosome-anagrams/https://chromosomesandcancer.com/wp-content/uploads/2014/12/chromothripsis-diagram.gifchromothripsis diagramThis shows how the chromosome shatters and rejoins in a random order. Note that the two ends of the chromosome and the centromere (represented by a circle) are preserved. These are essential features of a functioning linear chromosome. From MacKinnon and Campbell 2013. Cancer Genetics 206:238-251.https://chromosomesandcancer.com/wp-content/uploads/2014/12/chromothripsis-diagram.jpgChromothripsis diagramThis shows how the chromosome shatters and rejoins in a random order. Note that the two ends of the chromosome and the centromere (represented by a circle) are preserved. These are essential features of a functioning linear chromosome. From MacKinnon and Campbell 2013. Cancer Genetics 206:238-251.2014-12-10T14:34:28+00:00monthlyhttps://chromosomesandcancer.com/2014/10/19/sadakos-leukaemia-story-terror-joy-sickness-hope-in-a-new-short-film/https://chromosomesandcancer.com/wp-content/uploads/2014/10/sadako-and-golden-boat.jpgsadako and golden boathttps://chromosomesandcancer.com/wp-content/uploads/2014/10/sadako-and-golden-big.jpgsadako and golden bighttps://chromosomesandcancer.com/wp-content/uploads/2014/10/sadako-and-golden.jpgsadako and golden cranehttps://chromosomesandcancer.com/wp-content/uploads/2014/10/the-bridge-and-the-drawing.jpgthe bridge and the drawinghttps://chromosomesandcancer.com/wp-content/uploads/2014/10/snapshot-5-big-golden-crane.pngSnapshot 5 big golden crane2014-12-10T10:00:58+00:00monthlyhttps://chromosomesandcancer.com/2014/10/19/an-idea-a-film-and-a-lot-of-hope/https://chromosomesandcancer.com/wp-content/uploads/2014/10/sadako-statue-wiki.jpgsadako statue wikihttps://chromosomesandcancer.com/wp-content/uploads/2014/10/paper-thin-lizs-coming-shot1.pngpaper thin - liz's coming shot2014-10-18T23:14:25+00:00monthlyhttps://chromosomesandcancer.com/2014/07/13/carl-sagans-last-project-mds/2014-07-14T10:52:57+00:00monthlyhttps://chromosomesandcancer.com/2014/06/16/women-in-science-aspiration-and-inspiration/2014-06-16T12:08:35+00:00monthlyhttps://chromosomesandcancer.com/2014/04/20/mitosis-fun-with-modelling-clay/2014-04-20T20:25:02+00:00monthlyhttps://chromosomesandcancer.com/2014/02/28/rare-disease-day-28th-february-2014/2014-02-28T22:15:51+00:00monthlyhttps://chromosomesandcancer.com/2014/02/24/coming-soon-paper-thin/2014-02-24T10:31:30+00:00monthlyhttps://chromosomesandcancer.com/2014/02/09/why-isnt-there-more-research-into-my-disease-what-can-i-do-about-it/2014-04-03T06:13:13+00:00monthlyhttps://chromosomesandcancer.com/2014/01/06/chromosomes-that-cause-cancer-part-3-real-life-examples-of-the-bfb-cycle/https://chromosomesandcancer.com/wp-content/uploads/2014/01/f-rt174-hel-006-lep-nor-e1388882761170.jpgF-RT174-HEL.006 LEP NORThe red is DNA that's normally at one end of some of the chromosomes. The stripes tell us that the end of a chromosome (22) is in the middle of these chromosomes and there are extra copies. This helps us work out how these chromosomes were made. It's a strong clue that BFB cycles were involved and the ancestral chromosome had two centromeres.https://chromosomesandcancer.com/wp-content/uploads/2014/01/f-rt174-hel-014-a-nor1-e1388685658791.jpgF-RT174-HEL.014.A norThe red is from DNA at the end of some chromosomes - the stripes are from the end of chromosome 22, amplified by BFB cycles in a chromosome containing the 9 and 22 centromeres. 2014-01-07T11:02:30+00:00monthlyhttps://chromosomesandcancer.com/2013/11/03/chromosomes-that-cause-cancer-the-breakage-fusion-bridge-cycle/https://chromosomesandcancer.com/wp-content/uploads/2013/10/answer-to-ring-chr-e1380952305137.jpganswer to ring chrhttps://chromosomesandcancer.com/wp-content/uploads/2013/10/ring-chromosome-answer-e1380952012915.jpgring chromosome answerThe ring chromosomes are arrowed. They don't seem to have telomeres - no ends, no telomeres.https://chromosomesandcancer.com/wp-content/uploads/2013/10/bfb-with-oncogene-bb.jpgbfb with oncogene bbThe broken chromosomes in the new cell join together - the top daughter cell gets an extra copy of the yellow gene. The bottom cell loses this copy of yellow gene.https://chromosomesandcancer.com/wp-content/uploads/2013/10/bfb-with-oncogene-aa-e1380943476672.jpgbfb with oncogene aaThe new chromosome copies itself to make two equal halves.https://chromosomesandcancer.com/wp-content/uploads/2013/10/slide8.jpgSlide8The new chromosome with four copies of the yellow gene courtesy of the breakage-fusion-bridge cycle. https://chromosomesandcancer.com/wp-content/uploads/2013/10/slide7-e1381176044429.jpgSlide7Fusion of the broken bits of chromosome in the top cell.https://chromosomesandcancer.com/wp-content/uploads/2013/10/slide6-e1380940501992.jpgSlide6...the top daughter cell is now getting four copies of the yellow gene and the bottom cell is losing it's yellow genes.https://chromosomesandcancer.com/wp-content/uploads/2013/10/slide5.jpgSlide5If this process repeats..https://chromosomesandcancer.com/wp-content/uploads/2013/10/slide4-e1380940695114.jpgSlide4The broken chromosomes in the new cell join together - this cell gets an extra copy of the yellow gene.https://chromosomesandcancer.com/wp-content/uploads/2013/10/slide3-e1380940272670.jpgSlide3The bit of chromosome between them gets stretched and can break.2014-01-05T08:50:54+00:00monthlyhttps://chromosomesandcancer.com/2013/11/21/chromosomes-that-cause-cancer-part-2-the-philadelphia-chromosome/2013-11-27T09:41:36+00:00monthlyhttps://chromosomesandcancer.com/2013/11/01/something-completely-different-solar-lighting-making-a-difference-to-the-worlds-poorest-people/2013-11-03T05:13:53+00:00monthlyhttps://chromosomesandcancer.com/about/https://chromosomesandcancer.com/wp-content/uploads/2013/04/f-rt67-as-cens-012-a-fc-e1369749118520.jpgcentromeres - dicentric2014-11-04T19:06:50+00:00weekly0.6https://chromosomesandcancer.com/2013/09/19/the-cell-explained-in-the-new-fireside-science-blog-at-scifund-challenge/2013-09-20T08:39:43+00:00monthlyhttps://chromosomesandcancer.com/2013/08/09/telomeres-the-long-and-the-short-of-it/https://chromosomesandcancer.com/wp-content/uploads/2013/08/f-rt198-edpi44-020-atelog-ring-e1375969924413.jpgleukaemia telomeresThe green spots are telomeres on the blue chromosomes from a leukaemia cell. Spot the two abnormal "ring" chromosomes - no ends, no telomeres. 2013-12-29T05:34:47+00:00monthlyhttps://chromosomesandcancer.com/2013/07/27/art-meets-science-demonstrating-chromosome-division/https://chromosomesandcancer.com/wp-content/uploads/2013/07/slide9.jpgSlide9https://chromosomesandcancer.com/wp-content/uploads/2013/07/slide8.jpgSlide8https://chromosomesandcancer.com/wp-content/uploads/2013/07/slide7.jpgSlide7https://chromosomesandcancer.com/wp-content/uploads/2013/07/slide6.jpgSlide6https://chromosomesandcancer.com/wp-content/uploads/2013/07/slide5.jpgSlide5https://chromosomesandcancer.com/wp-content/uploads/2013/07/slide4.jpgSlide4https://chromosomesandcancer.com/wp-content/uploads/2013/07/slide3.jpgSlide3https://chromosomesandcancer.com/wp-content/uploads/2013/07/mitosis-1.jpgmitosis 1https://chromosomesandcancer.com/wp-content/uploads/2013/07/image.jpgimage2013-07-29T12:42:05+00:00monthlyhttps://chromosomesandcancer.com/what-are-chromosomes-and-dna/2013-07-21T09:14:45+00:00weekly0.6https://chromosomesandcancer.com/2013/07/17/behind-the-scenes-of-paper-thin-2/https://chromosomesandcancer.com/wp-content/uploads/2013/07/low-res-photo.jpglow res photohttps://chromosomesandcancer.com/wp-content/uploads/2013/07/stringing-cranes-low-res.jpgstringing cranes low res2013-07-18T10:38:50+00:00monthlyhttps://chromosomesandcancer.com/2013/07/07/the-last-frontier-of-the-human-genome-sequence-repetitive-dna/https://chromosomesandcancer.com/wp-content/uploads/2013/06/gnomes-front-and-back.jpgGnomes front and backFront and back cover of the 1991 Genome Mapping and Sequencing meeting at Cold Spring Harbor.2013-07-08T07:22:05+00:00monthlyhttps://chromosomesandcancer.com/about-this-blog/2013-06-29T13:37:58+00:00weekly0.6https://chromosomesandcancer.com/2013/06/10/is-cancer-the-most-common-genetic-disease/2013-06-20T21:27:49+00:00monthlyhttps://chromosomesandcancer.com/2013/06/18/the-human-genome-project-and-cancer/https://chromosomesandcancer.com/wp-content/uploads/2013/06/wellcome_genome_bookcase-2.pngWellcome_genome_bookcase 2https://chromosomesandcancer.com/wp-content/uploads/2013/06/photo-23.jpgphoto 22013-06-22T21:25:46+00:00monthlyhttps://chromosomesandcancer.com/2013/05/19/all-about-the-patients/2013-06-10T04:18:44+00:00monthlyhttps://chromosomesandcancer.com/2013/06/01/httpwww-pozible-comproject20784/2013-06-10T03:44:20+00:00monthlyhttps://chromosomesandcancer.comdaily1.02021-10-24T09:53:44+00:00